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Table 4 Scenario analysis results for RZV versus no HZ vaccine for selected Canadian adult IC populations

From: Cost-effectiveness and public health impact of recombinant zoster vaccine versus no herpes zoster vaccination in selected populations of immunocompromised adults in Canada

 

Median (90% UI)

ICER, $ per QALY gained

NNV to avoid

1 HZ case

1 PHN case

Breast cancer scenario

24,328 (15,010–39,864)

6 (4–9)

23 (16–37)

Renal transplant scenario

27,237 (8631–58,779)

6 (4–9)

42 (27–71)

HIV scenario

67,207 (39,698–115,403)

7 (5–11)

56 (36–92)

Hodgkin lymphoma scenario

81,470 (38,262–179,274)

7 (4–17)

38 (19–88)

  1. All costs are in 2022 Canadian dollars from a societal perspective
  2. HIV human immunodeficiency virus, HZ herpes zoster, IC immunocompromised, ICER incremental cost-effectiveness ratio, NNV number needed to vaccinate, PHN postherpetic neuralgia, QALY quality-adjusted life-year, RZV recombinant zoster vaccine, UI uncertainty interval